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名稱	Recombinant Human IL-3
型號
更新時間	2023-09-24
特點	Peprotech IL-3造血生長因子,促進生存、分化和增殖的巨核細(xì)胞的祖細(xì)胞。激活單核細(xì)胞的能力表明IL-3可能有額外的免疫調(diào)節(jié)作用。許多IL-3活動取決于co-stimulation與其他細(xì)胞因子。重組人類IL-3 15.0 kDa球狀蛋白質(zhì)含有133個氨基酸殘基。。使用所有無動物生產(chǎn)試劑。}

詳細(xì)內(nèi)容

一.產(chǎn)品名稱：Recombinant Human IL-3/Peprotech IL-3

二.Catalog Number:AF-200-03

三.Synonyms:MCGF (Mast cell growth factor), Multi-CSF, HCGF, P-cell stimulation factor

四.Description:

IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is species-specific, variably glycosylated cytokine. Recombinant human IL-3 is a 15.0 kDa globular protein containing 133 amino acid residues. . Manufactured using all non-animal reagents.

五.AA Sequence:

APMTQTTSLK TSWVNCSNMI DEIITHLKQP PLPLLDFNNL NGEDQDILME NNLRRPNLEA FNRAVKSLQN ASAIESILKN LLPCLPLATA APTRHPIHIK DGDWNEFRRK LTFYLKTLEN AQATTLSL AIF

六.Source:E.coli

七.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

八.Biological Activity:

The ED₅₀ was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10⁷ units/mg.

九.Cross Reactivity:Monkey, Human + Mouse, Human, Mouse