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名稱	Recombinant Human GM-CSF 美國Peprotech
型號
更新時間	2023-09-24
特點	gm - csf的造血生長因子刺激中性粒細胞和巨噬細胞的發(fā)展和促進早期的擴散和發(fā)展紅色的巨核細胞和嗜酸性粒細胞.生產(chǎn)的內(nèi)皮細胞,單核細胞、成纖維細胞和淋巴細胞。gm - csf抑制中性粒細胞遷移和增強的功能活動end-cells成熟。}

詳細內(nèi)容

一.產(chǎn)品名稱：Recombinant Human GM-CSF

二.Catalog Number:300-03

三.Synonyms:

Granulocyte/Macrophage Colony-Stimulating Factor, CSF-2, MGI-1GM, pluripoietin-α

四.Description:

GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant human GM-CSF is a 14.6 kDa globular protein consisting of 128 amino acids containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites.

五.AA Sequence:

MAPARSPSPS TQPWEHVNAI QEARRLLNLS RDTAAEMNET VEVISEMFDL QEPTCLQTRL ELYKQGLRGS LTKLKGPLTM MASHYKQHCP PTPETSCATQ IITFESFKEN LKDFLLVIPF DCWEPVQE

六.Source:E.coli

七.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

八.Biological Activity:

The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10⁷ units/mg.

九.Cross Reactivity:Human, Bacteria, Mouse, Leech, Pig, Human + Mouse